Identification of a novel low-affinity receptor for human interleukin-7
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چکیده
منابع مشابه
Identification of a distinct low-affinity receptor for human interleukin-4 on pre-B cells.
Biotinylated interleukin-4 (IL-4) was used to examine IL-4 receptor (IL-4R) expression on a range of human B-cell lines by flow cytometry. Using high concentrations of biotinylated IL-4, we have identified a novel low-affinity IL-4 receptor expressed at high levels on pre-B lines. Expression of this low-affinity receptor did not correlate with detected mRNA levels for the previously cloned rece...
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While IL-1 was initially described as a lymphocyte-activating factor (1), subsequent studies (2, 3) have shown that IL-1 regulates a variety of nonlymphoid cells involved in the inflammatory response . Prominent among these are connective tissue cells . While early studies demonstrated the ability of IL-I to stimulate proliferation by human dermal fibroblasts (4-6) and collagenase production by...
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We have conducted an in silico data base search for and cloned a novel G-protein-coupled receptor (GPCR) named TG1019. Dot and Northern blotting analyses showed that transcripts of the novel GPCR were expressed in various tissues except brain, and the expression was more intense in liver, kidney, peripheral leukocyte, lung, and spleen than in other tissues. By GTP S binding assay using the TG10...
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Native human IL-1 beta and IL-1 alpha stimulated prostaglandin E2 secretion by human embryonic lung fibroblasts at half-maximal concentrations of 3 +/- 1.2 pM (+/- SEM) and 10 +/- 2.3 pM, respectively. In contrast to the 20-50-fold lower affinities previously found for IL-1-R on 3T3 cells as well as murine and human lymphoblastoid lines, monoiodo 125I-IL-1 beta bound to normal human fibroblasts...
متن کاملRole of IgE Low-Affinity Receptor (CD23) in Pathogenesis of Nasal Polyp
Background: Nasal polyps, a common clinical problem, are characterized by eosinophilic and mast cell inflammation. The role of allergy and IgE in pathogenesis of nasal polyps is still unclear. IgE receptors are important components of the immunological pathway in allergic and inflammatory diseases. Objective: To determine if the low affinity IgE receptor (CD23) is presented on nasal polyp tis...
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ژورنال
عنوان ژورنال: Blood
سال: 1992
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v79.7.1738.bloodjournal7971738